| Autor: |
Mohammad Mehdi Dehghan, Elena Mahmoudi, Mohammad Ali Shohkrgozar, Baharak Emami, Mohammad Tafazoli-Shadpour, Suzan Amin, Nooshin Haghighipour, Mohammad Molazem, Seyyed Hossein Marjanmehr, Saeed Farzad Mohajeri, Yasamin Valy, Mir Sepehr Pedram |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Iranian Journal of Veterinary Surgery, Vol 11, Iss 2, Pp 21-30 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2008-3033 |
| Popis: |
Objective- Investigate myocardial performance after autologous adipose-derived (ASCs) mesenchymal stem cell differentiated under equiaxial cyclic strain, transplantation in rabbits with acute myocardial infarction (AMI). Design- Prospective, randomized experimental study Animals- 20 New Zealand White rabbits (2-3 kg) Procedure- ASCs were studied in four distinct groups of mechanical (ADM), chemical (ADC), undifferentiated (AD) and control (C) groups. According to this categorization, the cells were exposed to cyclic mechanical loading or 5-azacytidine as the chemical factor. 10 6 ASC cells were transplanted intramyocardially in rabbits with AMI (Acute Myocardial Infarction). Echocardiographic study was used to evaluate effects of cells on cardiac function. Results- Left ventricle ejection fraction (LVEF) was significantly increased in the ADM (mechanically-differentiated adipose-derived mesenchymal stem cell) group at 2 months follow-up. Fractional shortening (FS) also showed a similar pattern as LVEF and increased in ADM group in compare to control and AD (undifferentiated adipose-derived mesenchymal stem cell) group. Conclusion and clinical prevalence- The results indicate that intramyocardial transplantation of mechanically-differentiated ASCs improves cardiac function of ischemic myocardium. Transplantation of mechanically-differentiated ASCs for myocardial regeneration may become the future therapy for acute myocardial infarction. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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