Sex differences in asthma control, lung function and exacerbations: the ATLANTIS study
| Autor: | Salman Siddiqui, Thys van der Molen, Huib A M Kerstjens, Dave Singh, Chris Brightling, Maarten van den Berge, Alberto Papi, Klaus F Rabe, Leonardo M Fabbri, Monica Kraft, Martijn C Nawijn, Susan Muiser, Tessa M Kole |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | BMJ Open Respiratory Research, Vol 11, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2024-0023 2052-4439 |
| DOI: | 10.1136/bmjresp-2024-002316 |
| Popis: | Background Asthma is a heterogeneous disease with a prevalence and severity that differs between male and female patients.Question What are differences between male and female patients with asthma with regard to asthma control, lung function, inflammation and exacerbations?Methods We performed a post hoc analysis in the ATLANTIS (Assessment of Small Airways Involvement in Asthma) study, an observational cohort study including patients with asthma from nine countries with a follow-up of 1 year during which patients were characterised with measures of large and small airway function, questionnaires, inflammation and imaging. We compared differences in baseline characteristics and longitudinal outcomes between male and female patients with asthma.Results 773 patients were enrolled; 450 (58%) of these were female. At baseline, female patients with asthma were in higher Global Initiative for Asthma (GINA) steps (p=0.042), had higher Asthma Control Questionnaire 6 (F: 0.83; M: 0.66, p |
| Databáze: | Directory of Open Access Journals |
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