Mycoplasmosis in Ferrets

Autor: Matti Kiupel, Danielle R. Desjardins, Ailam Lim, Carole Bolin, Cathy A. Johnson-Delaney, James H. Resau, Michael M. Garner, Steven R. Bolin
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 18, Iss 11, Pp 1763-1770 (2012)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid1811.120072
Popis: We report an outbreak of severe respiratory disease associated with a novel Mycoplasma species in ferrets. During 2009–2012, a respiratory disease characterized by nonproductive coughing affected ≈8,000 ferrets, 6–8 weeks of age, which had been imported from a breeding facility in Canada. Almost 95% became ill, but almost none died. Treatments temporarily decreased all clinical signs except cough. Postmortem examinations of euthanized ferrets revealed bronchointerstitial pneumonia with prominent hyperplasia of bronchiole-associated lymphoid tissue. Immunohistochemical analysis with polyclonal antibody against Mycoplasma bovis demonstrated intense staining along the bronchiolar brush border. Bronchoalveolar lavage samples from 12 affected ferrets yielded fast-growing, glucose-fermenting mycoplasmas. Nucleic acid sequence analysis of PCR-derived amplicons from portions of the 16S rDNA and RNA polymerase B genes failed to identify the mycoplasmas but showed that they were most similar to M. molare and M. lagogenitalium. These findings indicate a causal association between the novel Mycoplasma species and the newly recognized pulmonary disease.
Databáze: Directory of Open Access Journals
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