| Autor: |
Elin S. Blom, Yijing Wang, Lena Skoglund, Anita C. Hansson, Massimo Ubaldi, Anbarasu Lourdusamy, Wolfgang H. Sommer, Matthew Mielke, Bradley T. Hyman, Markus Heilig, Lars Lannfelt, Lars N. G. Nilsson, Martin Ingelsson |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
International Journal of Alzheimer's Disease, Vol 2011 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
2090-0252 |
| DOI: |
10.4061/2011/936580 |
| Popis: |
Several components in the Wnt pathway, including β-catenin and glycogen synthase kinase 3 beta, have been implied in AD pathogenesis. Here, mRNA brain levels from five-month-old tg-ArcSwe and nontransgenic mice were compared using Affymetrix microarray analysis. With surprisingly small overall changes, Wnt signaling was the most affected pathway with altered expression of nine genes in tg-ArcSwe mice. When analyzing mRNA levels of these genes in human brain, transcription factor 7-like 2 (TCF7L2) and v-myc myelocytomatosis viral oncogene homolog (MYC), were increased in Alzheimer's disease (AD) (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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