| Autor: |
Hong-Yan Wang, Jian-Yang Chen, Yanan Li, Xianghui Zhang, Xiang Liu, Yifang Lu, Hang He, Yubang Li, Hongxi Chen, Qun Liu, Yingyi Huang, Zhao Jia, Shuo Li, Yangqing Zhang, Shenglei Han, Shuhong Jiang, Mingming Yang, Yingying Zhang, Li Zhou, Fujian Tan, Qianyue Ji, Liang Meng, Rui Wang, Yuyan Liu, Kaiqiang Liu, Qian Wang, Inge Seim, Jun Zou, Guangyi Fan, Shanshan Liu, Changwei Shao |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-024-51761-4 |
| Popis: |
Abstract Elucidating cellular architecture and cell-type evolution across species is central to understanding immune system function and susceptibility to disease. Adaptive immunity is a shared trait of the common ancestor of cartilaginous and bony fishes. However, evolutionary features of lymphocytes in these two jawed vertebrates remain unclear. Here, we present a single-cell RNA sequencing atlas of immune cells from cartilaginous (white-spotted bamboo shark) and bony (zebrafish and Chinese tongue sole) fishes. Cross-species comparisons show that the same cell types across different species exhibit similar transcriptional profiles. In the bamboo shark, we identify a phagocytic B cell population expressing several pattern recognition receptors, as well as a T cell sub-cluster co-expressing both T and B cell markers. In contrast to a division by function in the bony fishes, we show close linkage and poor functional specialization among lymphocytes in the cartilaginous fish. Our cross-species single-cell comparison presents a resource for uncovering the origin and evolution of the gnathostome immune system. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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