Modelling the Current Response and Sensitivity of Oxidase Enzyme Electrodes, Monitored Amperometrically by the Consumption of Oxygen

Autor: Pandy Pirabaharan, M. Chitra Devi, Rajagopal Swaminathan, Lakshmanan Rajendran, Michael E. G. Lyons
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Electrochem, Vol 3, Iss 2, Pp 309-321 (2022)
Druh dokumentu: article
ISSN: 2673-3293
DOI: 10.3390/electrochem3020021
Popis: Biosensor behaviour is characterised by non-linear differential equations that describe well-defined physical, chemical, and biological processes. Mathematical modelling of these biosensors is highly desirable since they have many applications. These models enable the prediction of a variety of their properties. In this study, the cyclic conversion of the substrate in an amperometric biosensor with an oxidase enzyme membrane electrode is studied using a mathematical model. The governing parameters for the Michaelis–Menten kinetics of enzymatic reactions are the enzyme kinetic and diffusion rates across the enzymatic layer. In this paper, we solved the non-linear equations analytically and numerically for all experimental values of parameters. This problem is simulated in MATLAB® v2016b software using the PDE solver. Our analytical solutions are compared to simulation results to validate the proposed model.
Databáze: Directory of Open Access Journals