Molecular characterization of the meq oncogene of Marek’s disease virus in vaccinated Brazilian poultry farms reveals selective pressure on prevalent strains
| Autor: | Ruy D. Chacón, Christian J. Sánchez-Llatas, Sarah L. Pajuelo, Andrea J. Diaz Forero, Victor Jimenez-Vasquez, Jack A. Médico, Luis F. Soto-Ugaldi, Claudete S. Astolfi-Ferreira, Antonio J. Piantino Ferreira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Veterinary Quarterly, Vol 44, Iss 1, Pp 1-13 (2024) |
| Druh dokumentu: | article |
| ISSN: | 01652176 1875-5941 0165-2176 |
| DOI: | 10.1080/01652176.2024.2318198 |
| Popis: | AbstractMarek’s disease virus (MDV) has become an increasingly virulent pathogen in the poultry industry despite vaccination efforts to control it. Brazil has experienced a significant rise of Marek’s disease (MD) outbreaks in recent years. Our study aimed to analyze the complete meq gene sequences to understand the molecular epidemiological basis of MD outbreaks in Brazilian vaccinated layer farms. We detected a high incidence rate of visceral MD (67.74%) and multiple circulating MDV strains. The most prevalent and geographically widespread genotype presented several clinical and molecular characteristics of a highly virulent strain and evolving under positive selective pressure. Phylogenetic and phylogeographic analysis revealed a closer relationship with strains from the USA and Japan. This study sheds light on the circulation of MDV strains capable of infecting vaccinated birds. We emphasize the urgency of adopting preventive measures to manage MDV outbreaks threatening the poultry farming industry. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|