| Autor: |
Dandan Zhao, Jiacheng Zuo, Na Yu, Xin Fang, Fangfang Mo, Rui Wu, Tian Tian, Rufeng Ma, Yushan Gao, Dongwei Zhang, Guangjian Jiang, Sihua Gao |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Journal of Traditional Chinese Medical Sciences, Vol 4, Iss 3, Pp 280-289 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2095-7548 |
| DOI: |
10.1016/j.jtcms.2017.07.003 |
| Popis: |
Objective: To determine the effect of Salvianolic acid B (Sal B) on glucose and lipid metabolism in mice with high-fat diet (HFD)-induced obesity, and to investigate the underlying mechanisms by measuring the expression levels of key adipogenic transcription factors. Methods: Six-week-old C57BL/6J male mice were fed for 12 weeks with a HFD to induce obesity or a standard diet to serve as normal controls. A mean body weight increase of more than 20% after these 12 weeks was used as the criteria for obesity. HFD-fed obese mice then received a supplement of Sal B (100 mg/kg body weight/day), metformin (75 mg/kg body weight/day) or water (an equivalent volume; served as model controls) by oral gavage for an additional 8 weeks, and the normal controls received water (an equivalent volume) by oral gavage for the same period. Results: Sal B significantly reduced body weight gain (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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