In-vitro anti-inflammatory evaluation of methanol and butanol extracts of Avocado pear (Persea americana mill) fruit peel
| Autor: | Hannah Okorie Ndidiamaka, Sunday Chidozie Umerie, Leonie Chisom Emeka, Jude Ali Ibeabuchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | African Journal of Pharmaceutical Research and Development (AJOPRED), Vol 15, Iss 3 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0794-800X 1596-2431 |
| Popis: | Inflammatory diseases such as arthritis, rheumatoid or non-rheumatoid joint inflammations are dominant among people all around the world. Plant-derived anti-inflammatory drugs are widely used against these disease conditions. This study investigated the in-vitro anti-inflammatory activity of the aqueous methanol and butanol extracts of Persea americana fruit peel. Three different concentrations of test samples: 10, 20 and 40 mg/ml from the concentrated methanol extract (ME) and butanol extracts (BE) were evaluated in vitro by albumin denaturation, heat induced hemolysis, antiproteinase action, anti-lipooxygenase spectrophotometric assay methods using aspirin as a reference drug. Results showed that at sample concentrations of 10, 20 and 40 mg/ml, the inhibition of albumin denaturation by the ME and BE were in the range 26.826-51.471 % and 40.329- 54.797 % respectively. The inhibition of heat-induced haemolysis by ME at the same concentrations was in the range 30.252-44.727% and 34.52-49.897% for BE. Anti-proteinase inhibitory activity for ME was within the range of 17.073-52.1 20% while 31 .781-37.01 4% was for BE. In all four assays, the BE elicited a relatively higher inhibitory activity than the ME. These suggest that the fruit extract possesses anti-inflammatory properties which may be attributed to the occurrence of bioactive compounds in the fruit peel. |
| Databáze: | Directory of Open Access Journals |
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