| Autor: |
HU Wei, ZHU Hengcheng, LI Haoyong, LIU Xiuheng, ZENG Yan |
| Jazyk: |
čínština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Zhongliu Fangzhi Yanjiu, Vol 47, Iss 3, Pp 194-197 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1000-8578 |
| DOI: |
10.3971/j.issn.1000-8578.2020.19.0776 |
| Popis: |
Objective To investigate the expression of CD248 (endosialin) in clear cell renal cell carcinoma (ccRCC) tissues and its clinical significance. Methods We collected fresh specimens from 17 ccRCC tissues and adjacent tissues, as well as paraffin specimens from 115 ccRCC tissues and adjacent tissues. qRT-PCR was used to detect the expression of CD248 mRNA in 17 cases of ccRCC tissues and corresponding adjacent tissues. Immunohistochemistry was used to detect the level of CD248 protein in paraffin-embedded specimens of 115 ccRCC patients. The correlation of CD248 expression with clinicopathological indicators and prognosis of ccRCC patients were analyzed. Results Compared with adjacent noncancerous tissues, CD248 mRNA expression (P=0.0026) and the average tissue immune response score (P=0.0061) were significantly higher in ccRCC specimens. The positive signal of CD248 protein was localized in the cytoplasm and part of the nucleus. The overall survival (OS) of high CD248 expression group was significantly lower than that of low CD248 expression group (44.4 vs. 57.2 months, P=0.017). Conclusion CD248 expression may be involved in the development of ccRCC. Compared with adjacent tissues, CD248 is highly expressed in ccRCC tissues. ccRCC patients with high CD248 expression have shorter survival time. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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