Genome wide association study for growth in Pakistani dromedary camels using genotyping-by-sequencing
| Autor: | Sajida Sabahat, Asif Nadeem, Rudiger Brauning, Peter C. Thomson, Mehar S. Khatkar |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Animal Bioscience, Vol 36, Iss 7, Pp 1010-1021 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2765-0189 2765-0235 |
| DOI: | 10.5713/ab.22.0181 |
| Popis: | Objective Growth performance and growth-related traits have a crucial role in livestock due to their influence on productivity. This genome-wide association study (GWAS) in Pakistani dromedary camels was conducted to identify single nucleotide polymorphisms (SNPs) associated with growth at specific camel ages, and for selected SNPs, to investigate in detail how their effects change with increasing camel age. This is the first GWAS conducted on dromedary camels in this region. Methods Two Pakistani breeds, Marecha and Lassi, were selected for this study. A genotyping-by-sequencing method was used, and a total of 65,644 SNPs were identified. For GWAS, weight records data with several body weight traits, namely, birthweight, weaning weight, and weights of camels at 1, 2, 4, and 6 years of age were analysed by using model-based growth curve analysis. Age-specific weight data were analysed with a linear mixed model that included fixed effects of SNP genotype as well as sex. Results Based on the q-value method for false discovery control, for Marecha camels, five SNPs at q |
| Databáze: | Directory of Open Access Journals |
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