| Autor: |
Ankit Bansal, Sana Tasnim, Mohit D. Gupta, Girish MP, Vishal Batra, Samantha Kohli, Sanjay Tyagi, M.A. Qadar Pasha |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Indian Heart Journal, Vol 73, Iss 4, Pp 511-515 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
0019-4832 |
| DOI: |
10.1016/j.ihj.2021.05.002 |
| Popis: |
Aim: Genetic contribution in acute rheumatic fever (ARF)/rheumatic heart disease (RHD) has been suggested but not according to severity of the valve involvement. This study attempts to identify the relevance of CTLA-4 polymorphism with severity of the disease. Methods: In a case-control design, 291 healthy controls and 83 patients were genotyped for association between RHD and single-nucleotide polymorphisms −1661A/G of CTLA-4. Results: Segregation of patients on the basis of severity i.e., MVL (Mitral Valve Lesion) and CVL (Combined Valve Lesion) revealed that the frequency of CTLA-4 −1661G allele depleted as the disease progressed to CVL (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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