| Autor: |
Edward N. Janoff, Sheldon T. Brown, Ilana Belitskaya-Levy, Jeffrey L. Curtis, Robert A. Bonomo, Elliott K. Miller, Alexa M. Goldberg, Lisa Zehm, Ashlea Wills, Caitlin Hutchinson, Larry J. Dumont, Theresa Gleason, Mei-Chiung Shih |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Contemporary Clinical Trials Communications, Vol 35, Iss , Pp 101190- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2451-8654 |
| DOI: |
10.1016/j.conctc.2023.101190 |
| Popis: |
Background: Effective therapeutics for severe acute respiratory syndrome CoronaVirus-2 (SARS-CoV-2) infection are evolving. Under Emergency Use Authorization, COVID-19 convalescent plasma (CCP) was widely used in individuals hospitalized for COVID-19, but few randomized controlled trials supported its efficacy to limit respiratory failure or death. Methods: VA CoronavirUs Research and Efficacy Studies-1 (VA CURES-1) was a double-blind, multi-site, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of CCP with conventional therapy in hospitalized Veterans with SARS-CoV-2 infection and early respiratory compromise (requirement for oxygen). Participants (planned sample size 702) were randomized 1:1 to receive CCP with high titer neutralizing activity or 0.9% saline, stratified by site and age (≥65 versus |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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