EVALUATION OF THREE RUBELLA VACCINES IN CONFERRING PROTECTION

Autor: K. Naficy, R. Nategh, M. Khakpour, M. Mohagheghpour, N. Sabouri
Jazyk: angličtina
Rok vydání: 1974
Předmět:
Zdroj: Iranian Journal of Public Health, Vol 3, Iss 3, Pp 117-127 (1974)
Druh dokumentu: article
ISSN: 2251-6085
Popis: The effeminacy of three rubella vaccines, HPV/77 IDE-5, Cendehill-51 and Wistar RA/27/3 in conferring immunity against untenanted rubella virus was compared. Vaccination resulted in 90-100 percent protection against clinical rubella. Intranasal challenge with the untenanted strain of rubella virus resulted in serologic evidence of in apparent reinfection in three of the ten Cendehill-51 vaccines the virus was isolated from the throat specimens of two, and one developed adenopathy. Two of the eleven RA/27/3 vaccines became reinfected. Virus was isolated from the throat specimen of one and a booster response occurred in that other; the latter developed rash. All of the HPV/177/DE-5 vaccines remained symptom less after the challenge. None demonstrated booster response and shed virus.
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