DIAGNOSTIC VALUE OF BRONCHOALVEOLAR LAVAGE IN LEUKEMIC AND BONE MARROW TRANSPLANT PATIENTS: THE IMPACT OF ANTIMICROBIAL THERAPY

Autor: John Norman Greene, Abraham Tareq Yacoub, Dani Thomas, Carol Yuan, Frank Walsh, David Solomon, Skai Schwartz, Arthur Andrews
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Mediterranean Journal of Hematology and Infectious Diseases, Vol 7, Iss 1, Pp e2015002-e2015002 (2014)
Druh dokumentu: article
ISSN: 2035-3006
DOI: 10.4084/mjhid.2015.002
Popis: Background Pneumonia carries significant morbidity and mortality in leukemic and bone marrow transplant patient. The development of pulmonary infiltrates in the setting of such immunocompromise raises concern for both infectious and non-infectious etiologies, some of which are potentially treatabl. Performing bronchoscopy provides several different options for sampling the lower respiratory tract. Among these, bronchoalveolar lavage (BAL) is especially effective at collecting samples from the alveoli and has been shown to be associated with less risk than transbonchial biops. We sought to examine the effect of antimicrobial treatment on BAL results in a large study population of leukemic and bone marrow transplant patients. Subjects and Methods This retrospective chart review was performed at a single academic cancer center. A power analysis was performed to determine the appropriate sample size. The patients were selected from those who had undergone an inpatient bronchoscopy in reverse chronological order until 300 patients with either a hematopoietic stem cell transplant or hematologic malignancy were identified. The exclusion criteria were age
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