Exercise limitation in hypertrophic cardiomyopathy: combined stress echocardiography and cardiopulmonary exercise test

Autor: Yonatan Erez, Eihab Ghantous, Aviel Shetrit, Ryan S. Zamanzadeh, David Zahler, Yoav Granot, Orly Ran Sapir, Michal Laufer Perl, Shmuel Banai, Yan Topilsky, Ofer Havakuk
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: ESC Heart Failure, Vol 11, Iss 4, Pp 2287-2294 (2024)
Druh dokumentu: article
ISSN: 2055-5822
DOI: 10.1002/ehf2.14776
Popis: Abstract Aims The study aims to investigate exercise‐limiting factors in hypertrophic cardiomyopathy (HCM) using combined stress echocardiography and cardiopulmonary exercise test. Methods and results A symptom‐limited ramp bicycle exercise test was performed in the semi‐supine position on a tilting dedicated ergometer. Echocardiographic images were obtained concurrently with gas exchange measurements along predefined stages of exercise. Oxygen extraction was calculated using the Fick equation at each activity level. Thirty‐six HCM patients (mean age 67 ± 6 years, 72% men, 18 obstructive HCM) were compared with age and sex‐matched 29 controls. At rest, compared with controls, E/E′ ratio (6.26 ± 2.3 vs. 14 ± 2.5, P
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