Cross-reactivity with Brazilian strains of B after immunization with outer membrane vesicles
| Autor: | Gabriela Trzewikoswki de Lima, Amanda Izeli Portilho, Elizabeth De Gaspari |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Vaccines and Immunotherapy, Vol 7 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2515-1363 25151355 74737813 |
| DOI: | 10.1177/2515135519894825 |
| Popis: | Background: Immunization against Neisseria meningitidis is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection. Methods: The cross-reactivity between three strains from the last outbreak of N. meningitidis in Brazil was assessed in our studies, using enzyme-linked immunosorbent assay (ELISA) and immunoblotting assays. Results: Both assays verifed a similar humoral response between the strains evaluated. Patterns of antigen recognition differed with each dose evaluated. Conclusions: We observed that immunization with N. meningitidis B outer membrane vesicles (OMVs) led to the production of antibodies that recognized antigens of heterologous strains, indicating possible protection against these evaluated strains. |
| Databáze: | Directory of Open Access Journals |
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