Treatment effectiveness and outcome in patients with a relapse and newly diagnosed multidrug-resistant pulmonary tuberculosis
| Autor: | Dmytro Butov, Valeriy Myasoedov, Mykola Gumeniuk, Galyna Gumeniuk, Oleksandra Choporova, Anton Tkachenko, Oleksandra Akymenko, Olena Borysova, Olena Goptsii, Yevhenii Vorobiov, Tetiana Butova |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Medicinski Glasnik, Vol 17, Iss 2, Pp 356-362 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1840-0132 1840-2445 |
| DOI: | 10.17392/1179-20 |
| Popis: | Aim To investigate the treatment effectiveness and outcome in patients with pulmonary tuberculosis relapse and newly diagnosed multidrug resistant pulmonary tuberculosis (MDR-TB). Methods A total of 240 pulmonary MDR-TB patients, including 114 ones with tuberculosis relapse and 126 cases of newly diagnosed pulmonary tuberculosis, were examined. Effectiveness of the basic antimycobacterial therapy course was evaluated based on the time to normalization of tuberculosis clinical manifestation, sputum culture and acid-fast bacilli stain conversion, cavity closure, disappearance of infiltrative and focal changes in the pulmonary tissue. Treatment outcomes were evaluated as cured, treatment completed, treatment failed, died and lost to follow-up according to the World Health Organization guidelines. Results When assessing the treatment effectiveness in patients with MDR-TB, a worse clinical and chest radiograph dynamics was observed in tuberculosis relapse against the background of high parameters of treatment failure (18.4 %) and low cured (34.2 %) compared with newly diagnosed pulmonary tuberculosis (7.1% and 58.7 %, respectively) (p=0.008 and p |
| Databáze: | Directory of Open Access Journals |
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