| Autor: |
Sara Rahgooy, Sepideh Arbabi Bidgoli, Saeed Shahbeigi, Shima Tavakol, Mohammad Hossein Salehi Surmaghi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Advanced Herbal Medicine, Vol 6, Iss 2, Pp 1-16 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2423-3579 |
| Popis: |
Background and aims:Current therapeutic regimens are not able to solve hormonal imbalance in young multiple sclerosis (MS) women and the clinical benefits of hormone therapy in MS patients remain controversial. This open labeled pilot study was aimed to find the role of Vitex agnus-castus plant supplement daily regimen in serum testosterone level , Expanded Disability Status Scale (EDSS), sexual function and overall quality of life in premenopausal MS patients. Methods: To achieve these goals, Molecular Docking on Vitex agnus-castus standard fruit extract constitutes performed and 30 eligible patients were selected for the clinical part of this study. Patients received two Vitagnus® film tablets in addition to their drugs for 90 days. Results: Some plant extract components showed strong affinity to Androgen Receptor Ligand binding domain. Significant reduction in EDSS (1.839 vs.1.643, p=0.003) and significant elevation in serum testosterone levels [388.6(±0.16900) vs. 468. (±0.18144) 2ng/dL (p=0.026)] were also observed at the completion of the intervention. Menstrual irregularities disappeared in all 28 patients who completed this study. MSQL-54 criteria at the completion of study (day 91) showed lower stress levels, improved vitality/emotional health and normalized sexual activities without significant effect on sleep disorders and cognitive functions of patients. Vitex agnus-castus treatment by predictable AR LBD affinity improved the emotional state, sexual life, EDSS score and overall quality of life in premenopausal RRMS patients. Conclusion: Our results suggest Vitagnus® film tablet as safe and promising supplement with some benefits in MS women who are suffering from disease induced emotional and sexual impairments. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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