| Autor: |
Gutiérrez Cristina, Maingon Philippe, Scalliet Pierre, Nguyen Tan, Belkacémi Yazid, Villette Sylviane, Amsler Beat, Zwahlen Daniel, Poortmans Philip, Epelbaum Ron, Taghian Alphonse, Jeanneret-Sozzi Wendy, Gastelblum Pauline, Krengli Marco, Raad Rita, Ozsahin Mahmut, Mirimanoff René-Olivier |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
BMC Cancer, Vol 8, Iss 1, p 86 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2407 |
| DOI: |
10.1186/1471-2407-8-86 |
| Popis: |
Abstract Background To asses the clinical profile, treatment outcome and prognostic factors in primary breast lymphoma (PBL). Methods Between 1970 and 2000, 84 consecutive patients with PBL were treated in 20 institutions of the Rare Cancer Network. Forty-six patients had Ann Arbor stage IE, 33 stage IIE, 1 stage IIIE, 2 stage IVE and 2 an unknown stage. Twenty-one underwent a mastectomy, 39 conservative surgery and 23 biopsy; 51 received radiotherapy (RT) with (n = 37) or without (n = 14) chemotherapy. Median RT dose was 40 Gy (range 12–55 Gy). Results Ten (12%) patients progressed locally and 43 (55%) had a systemic relapse. Central nervous system (CNS) was the site of relapse in 12 (14%) cases. The 5-yr overall survival, lymphoma-specific survival, disease-free survival and local control rates were 53%, 59%, 41% and 87% respectively. In the univariate analyses, favorable prognostic factors were early stage, conservative surgery, RT administration and combined modality treatment. Multivariate analysis showed that early stage and the use of RT were favorable prognostic factors. Conclusion The outcome of PBL is fair. Local control is excellent with RT or combined modality treatment but systemic relapses, including that in the CNS, occurs frequently. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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