Preventive Impacts of Selenium-Enriched Yeast on Liver and Enzyme Activity after Inducing Colorectal Cancer in Rat
| Autor: | Jamileh Abedi, Amir Tukmechi, Vahid Nejati, Rahim Hobbenaghi |
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| Jazyk: | perština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | مجله دانشکده پزشکی اصفهان, Vol 32, Iss 291, Pp 991-1003 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1027-7595 1735-854X |
| Popis: | Background: Colorectal cancer is the most common cause of death in the world. More studies were done on using the probiotics and selenium for cancer prevention. In this research, liver enzymes (such as alanine aminotransferase, asparate aminotransferase and alkaline phosphatase) changes were assessed following dietary administration of Saccharomyces cerevisiae (simple and selenium-enriched forms) in the rat with colorectal cancer induced by dimethyl hydrazine. Methods: Forty female rats, with 200-250 g initial body weight, were divided into five groups as healthy control, cancer control, simple form of yeast, selenium and selenium-enriched yeast. All animals received carcinogenic agent (40 mg/kg body weight) twice weekly for five weeks, except healthy controls which only received normal saline. Selenium group received 4 mg/ml of selenium nitrate in water; Saccharomyces cerevisiae was administered at the concentration of 5 × 108 CFU/ml with dimethyl hydrazine in yeast group; the last group received selenium-enriched yeast at the same concentration. At the end of forty weeks after Dimethyl hydrazine injection, all animals were euthanized and blood samples were taken for enzymes assay. Findings: Although the mean of enzymes activity were higher at cancer control, other groups significantly showed lower enzymes activity (P < 0.05). The most decrease of enzyme activity was seen in animals that received selenium-enriched yeast. Conclusion: The level of liver enzymes activity increases in colorectal cancer induced by dimethyl hydrazine in rat. Selenium-enriched yeast administration in rat could decreases the enzymes level and prevent tissue damage after carcinogenic agent injection. |
| Databáze: | Directory of Open Access Journals |
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