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Tegexibaiyin Wang,1,* Fen Liu,2,* Xiujuan Jia,3 Jing Tan,3 Baopeng Qi,4 Jingxue Guo,4 Qiri Mu,3 Hong Zhang5 1Laboratory of Pharmacy, International Mongolian Hospital of Inner Mongolia, Hohhot, 010065, People’s Republic of China; 2Department of Intensive Care Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, People’s Republic of China; 3Department of Dermatology, International Mongolian Hospital of Inner Mongolia, Hohhot, 010020, People’s Republic of China; 4Inner Mongolia Medical University, Hohhot, 010010, People’s Republic of China; 5Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, 250012, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiri Mu, Department of Dermatology, International Mongolian Hospital of Inner Mongolia, 83 University East Street, Hohhot, Inner Mongolia, 010020, People’s Republic of China, Email muqiri28@163.com Hong Zhang, Department of Pediatrics, Qilu Hospital, Shandong University, 107 Wenhua West Road, Jinan, 250012, People’s Republic of China, Email zhanghong681011@163.comBackground: The biomarker to predict the depression in patients with rosacea was absent.Objective: We aimed to explore the potential association between BDNF and depression in patients with rosacea, and also to determine whether serum BDNF level is a potential biomarker for identifying depression in patients with rosacea.Methods: The patients with rosacea, rosacea with depression and healthy control were included, clinical evaluation (DLQI, RSSs, BDI-II) and serum BDNF levels detection were performed on subjects, the comparisons and correlation analysis of the obtained data were performed.Results: In clinical evaluation, whether DLQI or RSSs, rosacea with depression group was significantly higher compared to rosacea group. Besides, we found the serum BDNF levels were lower in patients with rosacea and rosacea with depression compared to healthy controls, also in the rosacea with depression group, serum BDNF levels were lower than in rosacea patients. Whatever in rosacea or rosacea with depression group, the statistical significance of serum BDNF levels between the different subtypes like the ETR and PPR was not found. In further correlation analysis, we found no correlation between serum BDNF and RSSs in patients with rosacea whatever the subtype of ETR or PPR. Interestingly, we found a negative correlation between serum BDNF levels and BDI-II in rosacea with depression group, the decreased serum BDNF levels were associated with the increased BDI-II, also the ROC confirmed it can evaluate the depression in patients with rosacea.Conclusion: Serum BDNF level is a potential biomarker for identifying depression in patients with rosacea.Keywords: rosacea, biomarker, brain-derived neurotrophic factor, depression |
