Effect of once versus twice intracoronary injection of allogeneic-derived mesenchymal stromal cells after acute myocardial infarction: BOOSTER-TAHA7 randomized clinical trial

Autor:	Armin Attar, Mohsen Farjoud Kouhanjani, Kamran Hessami, Massoud Vosough, Javad Kojuri, Mani Ramzi, Seyed Ali Hosseini, Marjan Faghih, Ahmad Monabati
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Myocardial infarction Mesenchymal stromal cell Intracoronary injection Ventricular function Stroke volume Medicine (General) R5-920 Biochemistry QD415-436
Zdroj:	Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2023)
Druh dokumentu:	article
ISSN:	1757-6512
DOI:	10.1186/s13287-023-03495-1
Popis:	Abstract Background Mesenchymal stromal cell (MSC) transplantation can improve the left ventricular ejection fraction (LVEF) after an acute myocardial infarction (AMI). Transplanted MSCs exert a paracrine effect, which might be augmented if repeated doses are administered. This study aimed to compare the effects of single versus double transplantation of Wharton’s jelly MSCs (WJ-MSCs) on LVEF post-AMI. Methods We conducted a single-blind, randomized, multicenter trial. After 3–7 days of an AMI treated successfully by primary PCI, 70 patients younger than 65 with LVEF
Databáze:	Directory of Open Access Journals
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