Iron deficiency in new onset heart failure: association with clinical factors and quality of life

Autor: Carin Corovic Cabrera, Mattias Ekström, Per Tornvall, Ulrika Löfström, Christoffer Frisk, Cecilia Linde, Camilla Hage, Hans Persson, Maria J. Eriksson, Håkan Wallén, Bengt Persson, Patrik Lyngå
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: ESC Heart Failure, Vol 11, Iss 5, Pp 2661-2671 (2024)
Druh dokumentu: article
ISSN: 2055-5822
DOI: 10.1002/ehf2.14849
Popis: Abstract Aims The prevalence of iron deficiency (ID) in newly diagnosed heart failure (HF) and the progression of ID in patients after initiation of HF therapy are unknown. We aimed to describe the natural trajectory of ID in patients with new onset HF during the first year after HF diagnosis, assessing associations between ID, clinical factors, and quality of life (QoL). Methods and results A prospective cohort of patients with new onset HF in hospitals or outpatient clinics at five major hospitals in Stockholm, Sweden, during 2015–2018 were analysed with clinical assessment, electrocardiogram, blood samples including iron levels, Minnesota living with heart failure questionnaire (MLHFQ), and echocardiogram at baseline and after 12 months. Of 547 patients with new‐onset HF, 482 (88%) had complete iron data at baseline. Median age was 70 years (interquartile range 61–77) and 311 (65%) were men; 55% of patients had ejection fraction (EF) ≤ 40%, 19% had EF 41–49%, and 26% had HF with preserved EF (HFpEF) [Correction added on 26 June 2024, after first online publication: The ‘Mean age was 70 years’ has been corrected to ‘Median age was 70 years’ in this version.]. At baseline, 163 patients (34%) had ID defined as ferritin
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