VEGF Mediates Tumor Growth and Metastasis by Affecting the Expression of E-Cadherin and N-Cadherin Promoting Epithelial to Mesenchymal Transition in Gastric Cancer

Autor: Yue Zhang, Yanyan Wang, Menglin Zhao, Xinwei Li, Huiyuan Li, Mingyue Tang, Zhijun Geng, Lugen Zuo, Xue Song, Zishu Wang, Qiang Wang, Fang Su
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Clinical Medicine Insights: Oncology, Vol 17 (2023)
Druh dokumentu: article
ISSN: 1179-5549
11795549
DOI: 10.1177/11795549231175715
Popis: Background: Gastric cancer (GC) is the fifth leading cancer in the world, and there is a high mortality rate in China. Exploring the relationship between the prognosis of GC and the expression of related genes is helpful to further understand the common characteristics of the occurrence and development of GC and provide a new method for the identification of early GC, so as to provide the best therapeutic targets. Methods: Vascular endothelial growth factor (VEGF) and markers of epithelial-mesenchymal transition (EMT) were investigated immunohistochemically using tumor samples obtained from 196 GC tissues and adjacent tumor tissues. The correlation of the expression level with histopathologic features and survival was investigated. Results: Here, we show that VEGF and EMT markers expression were significantly correlated with depth of tumor invasion and GC stage ( P
Databáze: Directory of Open Access Journals
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