Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells

Autor: Holly Rore, Nicholas Owen, Raul Eduardo Piña-Aguilar, Kevin Docherty, Ryohei Sekido
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02322-8
Popis: Rore et al generate testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture. They created testicular organoids in aggregation co-culture of TesLCs and epiblast-like cells (EpiLCs) and also find that TesLC-conditioned media promotes the differentiation of EpiLCs into primordial germ-like cells (PGCLCs).
Databáze: Directory of Open Access Journals
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