MCM6 versus Ki-67 in diagnosis of luminal molecular subtypes of breast cancers

Autor: Dorsay Sadeghian, Hana Saffar, Pouya Mahdavi Sharif, Vahid Soleimani, Behnaz Jahanbin
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Diagnostic Pathology, Vol 17, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 1746-1596
DOI: 10.1186/s13000-022-01209-4
Popis: Abstract Background Currently, breast cancers are divided into four major molecular subtypes. The distinction between the luminal A and luminal B subtypes is mainly based on the cellular proliferation indices and is assessed by the Ki-67 scoring. Due to the limitations in the assessment and expression of Ki-67, we hypothesized that minichromosome maintenance protein 6 (MCM6) might be taken as a surrogate marker to differentiate molecular subtypes and aid in more precise grading of tumors. Methods We performed a retrospective, cross-sectional study on 124 samples of breast cancer and 40 samples of normal breast tissue. Relevant clinical information was retrieved from the Cancer Institute database. Results MCM6 could discriminate between various categories of histologic grades, tubule formation, mitotic indices, and nuclear pleomorphism (P = 0.002 for tubule formation and P
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