Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice

Autor:	Ender Yarsan, Arif Altıntas, Dinc Essiz, Levent Altintas, Mert Pekcan, Gulay Ciftci, Ishraga G. Ibrahim
Jazyk:	angličtina
Předmět:	sulphamethoxazole pharmacokinetic renal failure mercury chloride Veterinary medicine SF600-1100
Zdroj:	Eurasian Journal of Veterinary Sciences, Vol 26, Iss 1, Pp 21-24
Druh dokumentu:	article
ISSN:	1309-6958 2146-1953
Popis:	Aim: The effects of renal failure on the pharmacokinetics of sulphamethoxazole were investigated after oral administration of 100 mg/kg of the drug using a mice model of mercury chloride-induced renal failure. Materials and Methods: Mercury chloride was given to mice at the doses of 3 and 6 mg/kg. Plasma sulphamethoxazole concentrations were measured by spectrophotometer. Plasma concentration-time data were fitted to a two-compartment open model. Results: Significant findings (p1/2a) and elimination (t1/2β and MRT) phases of sulphamethoxazole related with renal failure. Also area under the curve value decreased, and mean residence time value increased with renal failure (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c9afaa5552134179b0cbd1a0e2b0392e Zobrazit plný text záznamu View record in DOAJ