A review of current developments in RNA modifications in lung cancer

Autor:	Shujun Zhang, Yafeng Liu, Kaijie Liu, Xinjun Hu, Xinyu Gu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Epigenetic RNA modification Lung cancer NSCLC Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Zdroj:	Cancer Cell International, Vol 24, Iss 1, Pp 1-16 (2024)
Druh dokumentu:	article
ISSN:	1475-2867
DOI:	10.1186/s12935-024-03528-6
Popis:	Abstract Lung cancer has the highest incidence and mortality rates worldwide and is the primary cause of cancer-related death. Despite the rapid development of diagnostic methods and targeted drugs in recent years, many lung cancer patients do not benefit from effective therapies. The emergence of drug resistance has led to a reduction in the therapeutic effectiveness of targeted drugs, highlighting a crucial need to explore novel therapeutic targets. Many studies have found that epigenetic plays an important role in the occurrence of lung cancer. This review describes the biological function of epigenetic RNA modifications, such as m6A, m5C, m7G, and m1A, and recent advancements in their role in the development, progression, and prognosis of lung cancer. This review aims to provide new guidance for the treatment of lung cancer.
Databáze:	Directory of Open Access Journals
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