Can the FIB-4 score predict the severity of acute pancreatitis in NAFLD?

Autor: Kutay Kirdok, Özge Yogurtcu, Tahir Buran, Elmas Kasap
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Egyptian Liver Journal, Vol 14, Iss 1, Pp 1-4 (2024)
Druh dokumentu: article
ISSN: 2090-6226
DOI: 10.1186/s43066-024-00313-y
Popis: Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a liver pathology. NAFLD’s prevalence is increasing in the world and because of the increase non-invasive methods are gaining importance in diagnosis. The Fibrosis 4 (FIB-4) score is one of the most commonly used non-invasive scoring methods for diagnosing NAFLD today. Acute pancreatitis is a disease with inflammation and high morbidity. There are studies indicating that acute pancreatitis progresses more severely in patients with NAFLD. In our study, it was aimed to define the possible relationship between the FIB-4 score and the severity of acute pancreatitis, which has not been investigated before and contribute to the literature. Methods Our study was conducted by retrospectively scanning 124 patients diagnosed with acute pancreatitis between 2018 and 2020. The patients were compared with the presence of NAFLD and the FIB-4 score results in those with NAFLD. Results The 48th-hour Ranson score was found to be statistically significantly higher in patients with NAFLD compared to those without NAFLD. In patients with NAFLD, the total billurbin, direct billurbin, AST, ALT, ALP, GGT, and Ranson scores were found to be statistically significantly higher in those with FIB-4 score ≥ 2.67. Conclusıon As liver fibrosis increases in patients with NAFLD, it is suggested that liver damage accompanying acute pancreatitis increases, and the prognosis of acute pancreatitis worsens. There is a need for further studies to be conducted while centering more on this subject, which has not been investigated before in the literature.
Databáze: Directory of Open Access Journals
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