The EGF/EGFR axis and its downstream signaling pathways regulate the motility and proliferation of cultured oral keratinocytes

Autor: Ryota Kobayashi, Emi Hoshikawa, Taisuke Saito, Orakarn Suebsamarn, Eriko Naito, Ayako Suzuki, Seiichiro Ishihara, Hisashi Haga, Kei Tomihara, Kenji Izumi
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: FEBS Open Bio, Vol 13, Iss 8, Pp 1469-1484 (2023)
Druh dokumentu: article
ISSN: 2211-5463
DOI: 10.1002/2211-5463.13653
Popis: We previously reported that the cell and colony motion of oral keratinocytes are correlated with proliferative capacity, and speculated that this may be a specific index for monitoring cell quality. However, how cell motility and proliferation are regulated by signaling pathways remains unelucidated. Here, we found that the regulation of cell motility and proliferative capacity of oral keratinocytes can be attributed to the epidermal growth factor/epidermal growth factor receptor (EGF/EGFR) axis. The EGFR downstream cascade involving the Src/PI3K/Akt/mTOR signaling pathway showed a major effect on cell motility and proliferative capacity in oral keratinocytes. Furthermore, both EGFR and Src attenuated E‐cadherin expression. Taken together, these findings provide a potential basis for future quality control of cells for therapeutic use.
Databáze: Directory of Open Access Journals