Increased glycated albumin and decreased esRAGE levels in serum are related to negative coronary artery remodeling in patients with type 2 diabetes: an Intravascular ultrasound study

Autor:	Run Du, Rui Yan Zhang, Lin Lu, Ying Shen, Li Jin Pu, Zheng Bin Zhu, Qi Zhang, Jian Hu, Zhen Kun Yang, Feng Hua Ding, Jian Sheng Zhang, Wei Feng Shen
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Coronary remodeling Intravascular ultrasound esRAGE Glycated albumin Diabetes mellitus Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-10 (2018)
Druh dokumentu:	article
ISSN:	1475-2840
DOI:	10.1186/s12933-018-0792-y
Popis:	Abstract Background Negative coronary artery remodeling is frequent in patients with diabetes, but its mechanism remains unclear. We here evaluated the association of serum levels of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) with coronary artery remodeling in type 2 diabetic patients. Methods Serum levels of GA and esRAGE were measured and intravascular ultrasound was performed in 136 consecutive diabetic patients with 143 coronary intermediate lesions. The remodeling index (RI) was calculated as the ratio between external elastic membrane (EEM) area at the lesion site and EEM area at the reference segment. Negative remodeling (NR) was defined as an RI
Databáze:	Directory of Open Access Journals
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