| Autor: |
Calafell Francesc, Banuls Enrique, Volpini Victor, Sinol Nuria, Trujols Joan, Baiget Montserrat, Perez de los Cobos Jose, Luquero Elena, del Rio Elisabeth, Alvarez Enric |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Behavioral and Brain Functions, Vol 3, Iss 1, p 25 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1744-9081 |
| DOI: |
10.1186/1744-9081-3-25 |
| Popis: |
Abstract Background Conflicting associations with heroin dependence have been found involving the A1 allele of dopamine D2 receptor gene (DRD2) TaqI A polymorphism. Methods We compared two samples of unrelated Spanish individuals, all of European origin: 281 methadone-maintained heroin-dependent patients (207 males and 74 females) who frequently used non-opioid substances, and 145 control subjects (98 males and 47 females). Results The A1-A1 genotype was detected in 7.1% of patients and 1.4% of controls (P = 0.011, odds ratio = 5.48, 95% CI 1.26–23.78). Although the A1 allele was not associated with heroin dependence in the entire sample, the frequency of A1 allele was higher in male patients than in male controls (24.4% vs. 16.3%, P = 0.024, odds ratio = 1.65, 95% CI 1.07–2.57). A logistic regression analysis showed an interaction between DRD2 alleles and gender (odds ratio = 1.77, 95% CI 1.15–2.70). Conclusion Our results indicate that, in Spanish individuals, genotypes of the DRD2 TaqI A polymorphism contribute to variations in the risk of heroin dependence, while single alleles contribute only in males. |
| Databáze: |
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| Externí odkaz: |
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