| Autor: |
Pei-Wei Wang, Yu-Fang Huang, Chung-Hao Wang, Li-Jung Fang, Mei-Lien Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Pediatrics and Neonatology, Vol 65, Iss 1, Pp 76-84 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1875-9572 |
| DOI: |
10.1016/j.pedneo.2023.04.011 |
| Popis: |
Background: Nonylphenol (NP) and bisphenol A (BPA) are produced in large quantities worldwide as multipurpose agents. However, studies on relations between NP and BPA exposure and childhood neurodevelopment are few, and the results are inconsistent. This study aimed to investigate associations between prenatal and early childhood NP and BPA exposure and neurodevelopment in mother–child pairs. Methods: Pregnant women at 27–38 weeks' gestation were recruited, as were children 2–3 years of age (n = 94) and 4–6 years of age (n = 56) years. Urine was collected to assess NP and BPA exposure. Bayley Scales of Infant and Toddler Development (3rd edition; Bayley-III), Wechsler Preschool and Primary Scale of Intelligence (4th edition), and the Full Scale Intelligence Quotient (WPPSI-IV-FSIQ) were used to assess the neurodevelopment of the children. Results: The detection rate and concentration of NP and BPA in the urine of children 4–6 years old were higher than in those 2–3 years old. Children were divided into a high concentration group (3rd tertile) and a reference group (1st and 2nd tertiles) based on natural log-transformed urine concentration of NP and BPA. Girls' Bayley-III motor scores in the high concentration group were higher than those of the BPA reference group of urine of mothers (β = 6.85, 95% confidence interval [CI]: 1.58–12.13). Boys' FSIQ in the higher concentration group were significantly lower than those in children 2–3 years old in the NP reference group (β = −11.29, 95% CI: −18.62 to −3.96) (all, p |
| Databáze: |
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| Externí odkaz: |
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