TLR7 Modulated T Cell Response in the Mesenteric Lymph Node of Schistosoma japonicum-Infected C57BL/6 Mice

Autor: Jiale Qu, Xiuxue Yu, Chenxi Jin, Yuanfa Feng, Shihao Xie, Hongyan Xie, Quan Yang, Yanwei Qi, Huaina Qiu, Hongyuan Chen, Jianbing Mu, Yi Zhou, Jun Huang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Immunology Research, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 2314-8861
2314-7156
DOI: 10.1155/2019/2691808
Popis: Toll-like receptors (TLRs) play an important role in regulating immune responses during pathogen infection. However, roles of TLRs on T cells reside in the mesenteric lymph node (MLN) were not be fully elucidated in the course of S. japonicum infection. In this study, T lymphocytes from the mesenteric lymph node (MLN) of S. japonicum-infected mice were isolated and the expression and roles of TLR2, TLR3, TLR4, and TLR7 on both CD4+ and CD8+ T cells were compared. We found that the expression of TLR7 was increased in the MLN cells of S. japonicum-infected mice, particularly in CD4+ and CD8+ T cells (P
Databáze: Directory of Open Access Journals
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