A LASSO-based model to predict central lymph node metastasis in preoperative patients with cN0 papillary thyroid cancer
| Autor: | Feng Zhao, Ping Wang, Chaoran Yu, Xuefei Song, Hui Wang, Jun Fang, Chenfang Zhu, Yousheng Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
papillary thyroid carcinoma (PTC)
central lymph node metastasis (CLNM) least absolute shrinkage and selection operator (LASSO) nomogram prediction model clinically negative central compartment lymph nodes (cN0) prophylactic central lymph node dissection (PCLND) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| Zdroj: | Frontiers in Oncology, Vol 13 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2023.1034047 |
| Popis: | IntroductionCentral lymph node metastasis (CLNM) is common in papillary thyroid carcinoma (PTC). Prophylactic central lymph node dissection (PCLND) in clinically negative central compartment lymph node (cN0) PTC patients is still controversial. How to predict CLNM before the operation is very important for surgical decision making.MethodsIn this article, we retrospectively enrolled 243 cN0 PTC patients and gathered data including clinical characteristics, ultrasound (US) characteristics, pathological results of fine-needle aspiration (FNA), thyroid function, eight gene mutations, and immunoenzymatic results. Least absolute shrinkage and selection operator (LASSO) analysis was used for data dimensionality reduction and feature analysis.ResultsAccording to the results, the important predictors of CLNM were identified. Multivariable logistic regression analysis was used to establish a new nomogram prediction model. The receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) curve were used to evaluate the performance of the new prediction model.DiscussionThe new nomogram prediction model was a reasonable and reliable model for predicting CLNM in cN0 PTC patients, but further validation is warranted. |
| Databáze: | Directory of Open Access Journals |
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