Involvement of hippocampal AMPA glutamate receptor changes and the cAMP/protein kinase A/CREB-P signalling pathway in memory consolidation of an avoidance task in rats

Autor: R. Bernabeu, M. Cammarota, I. Izquierdo, J.H. Medina
Jazyk: angličtina
Rok vydání: 1997
Předmět:
Zdroj: Brazilian Journal of Medical and Biological Research, Vol 30, Iss 8, Pp 961-965 (1997)
Druh dokumentu: article
ISSN: 0100-879X
1414-431X
DOI: 10.1590/S0100-879X1997000800008
Popis: Training in step-down inhibitory avoidance (0.3-mA footshock) is followed by biochemical changes in rat hippocampus that strongly suggest an involvement of quantitative changes in glutamate AMPA receptors, followed by changes in the dopamine D1 receptor/cAMP/protein kinase A (PKA)/CREB-P signalling pathway in memory consolidation. AMPA binding to its receptor and levels of the AMPA receptor-specific subunit GluR1 increase in the hippocampus within the first 3 h after training (20-70%). Binding of the specific D1 receptor ligand, SCH23390, and cAMP levels increase within 3 or 6 h after training (30-100%). PKA activity and CREB-P levels show two peaks: a 35-40% increase 0 h after training, and a second increase 3-6 h later (35-60%). The results correlate with pharmacological findings showing an early post-training involvement of AMPA receptors, and a late involvement of the D1/cAMP/PKA/CREB-P pathway in memory consolidation of this task
Databáze: Directory of Open Access Journals
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