EFFICACY AND SAFETY OF COMBINATION TREATMENT WITH ABATACEPT AND METHOTREXATE AND MONOTHERAPY WITH METHOTREXATE IN PATIENTS WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS
| Autor: | V. A. Kel'tsev, L. I. Grebenkina, N. S. Pryanichkova, S. А. Gorunov, N. V. Lagoda |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Вопросы современной педиатрии, Vol 11, Iss 6, Pp 103-109 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1682-5527 1682-5535 |
| DOI: | 10.15690/vsp.v11i6.500 |
| Popis: | The results of efficacy and safety study of abatacept and methotrexate combination therapy (n=12) in comparison with methotrexate monotherapy (n =41) in patients with polyarticular juvenile idiopathic arthritis at the age of 4–17 years old are shown in this article. The duration of the observation was 1 year. Abatacept was introduced at a dose of 10 mg/kg at 1st, 2d and then — every 4th week. In 48 weeks clinical remission and decrease of laboratory markers of activity was registered in 35% of patients treated with abatacept and methotrexate and in 16% of patients treated only with methotrexate. |
| Databáze: | Directory of Open Access Journals |
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