BT3 molecules ligation enhances the proinflammatory responses of human monocytes and monocyte-derived dendritic cells

Autor:	R. Simone, A. Rabellino, G. Icardi, M. Bagnasco, G. Pesce, D. Olive, D. Saverino
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	BT3 B7 family monocytes dendritic cells Toll-like receptors Biology (General) QH301-705.5
Zdroj:	Journal of Biological Research, Vol 84, Iss 1 (2011)
Druh dokumentu:	article
ISSN:	1826-8838 2284-0230
DOI:	10.4081/jbr.2011.4664
Popis:	BT3, a new family of immunoreceptors, belongs to the extended B7 family. BT3 are expressed on the surface of resting and activated monocytes and monocytes-derived dendritic cells (iDC). We show that BT3 cross-linking, in the absence of other survival factors, provides a survival signal for monocytes. We further analysed the effects of BT3 cross-linking on various proinflammatory responses. Results obtained showed that BT3 engagements is able to modulate production of IL8/CXCL8, IL-I b and IL-I 2/p70. Moreover, we demostrated a co-stimulatory effect of BT3 receptors.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9ab0b7e1c0ed48ad88fb710a01e7ea15 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF