Significance of platelet count in esophageal carcinomas

Autor: Ali Aminian, Faramarz Karimian, Rasoul Mirsharifi, Abbas Alibakhshi, Habibollah Dashti, Yosra Jahangiri, Saeed Safari, Hamid Ghaderi, Morteza Noaparast, Sharareh M Hasani, Alireza Mirsharifi
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: The Saudi Journal of Gastroenterology, Vol 17, Iss 2, Pp 134-137 (2011)
Druh dokumentu: article
ISSN: 1319-3767
1998-4049
DOI: 10.4103/1319-3767.77245
Popis: Background/Aim: Thrombocytosis is found to be associated with unfavorable prognosis in esophageal carcinoma. Platelets produce thymidine phosphorylase which is a platelet-derived endothelial cell growth factor with angiogenic activity. Increased platelet count may be translated into enhanced tumor growth. We examined the relation between platelet count and several prognostic variables in patients with esophageal cancer. Patients and Methods: Three hundred and eighty-one cases with esophageal cancer that underwent esophagectomy in a referral cancer institute during a 5-year period were studied retrospectively. The relation between preoperative platelet count and patient age, gender, site of tumor, presence of multiple cancers and clinicopathological characteristics including histological type, tumor size, depth of penetration (T), lymph node involvement (N), distant metastasis (M), degree of differentiation, presence of vascular, lymphatic and perineural invasion was examined. Results: Squamous cell carcinoma (SCC) constituted 93% and adenocarcinoma 7% of cases. Most of patients were in stage III, followed by stage II. The mean platelet count was 245±76 (Χ 10 9 /L). There was no statistically significant correlation between platelet counts with prognostic factors except a weak linear correlation between platelet count and and tumor size (P= 0.03, Pearson correlation coefficient: 0.16). Patients with adenocarcinoma had a higher platelet count than those with SCC (P= 0.003). Conclusion: Platelet count does not correlate with prognostic factors in esophageal cancer. However, it is significantly different between SCC and adenocarcinoma of esophagus.
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