Is compromised intestinal barrier integrity responsible for the poor prognosis in critically ill patients with pre-existing hyperglycemia?

Autor: Yi-Feng Wang, Feng-Ming Liang, Min Liu, Li-Cheng Ding, Jiao-Jie Hui, Hong-Yang Xu, Li-Jun Liu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 1758-5996
DOI: 10.1186/s13098-022-00943-5
Popis: Abstract Background Compromised intestinal barrier integrity can be independently driven by hyperglycemia, and both hyperglycemia and intestinal barrier injury are associated with poor prognosis in critical illness. This study investigated the intestinal barrier biomarkers in critically ill patients, to explore the role of compromised intestinal barrier integrity on the prognosis of critically ill patients with pre-existing hyperglycemia. Methods This was a retrospective observational study. The relationships between intestinal barrier biomarkers and glycated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), indicators of clinical characteristics, disease severity, and prognosis in critically ill patients were investigated. Then the metrics mentioned above were compared between survivors and non-survivors, the risk factors of 90-day mortality were investigated by logistic regression analysis. Further, patients were divided into HbA1c
Databáze: Directory of Open Access Journals
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