The Application of Single-Cell RNA Sequencing in Vaccinology

Autor: Andrés Noé, Tamsin N. Cargill, Carolyn M. Nielsen, Andrew J. C. Russell, Eleanor Barnes
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Immunology Research, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2314-8861
2314-7156
DOI: 10.1155/2020/8624963
Popis: Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher the immune response to infectious diseases and vaccines. Here, we describe the potential uses of single-cell RNA sequencing methods in prophylactic vaccine development, concentrating on infectious diseases including COVID-19. Using examples from several diseases, we review how single-cell RNA sequencing has been used to evaluate the immunological response to different vaccine platforms and regimens. By highlighting published and unpublished single-cell RNA sequencing studies relevant to vaccinology, we discuss some general considerations how the field could be enriched with the widespread adoption of this technology.
Databáze: Directory of Open Access Journals
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