Visualization of invisible cell-death sign by electric-double-layer modulation

Autor: Jun'ya Tsutsumi, Jun Kurosu, Kaname Kanai, Kingo Uchida, Kana Morishita, Kimio Sumaru
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Biosensors and Bioelectronics: X, Vol 14, Iss , Pp 100390- (2023)
Druh dokumentu: article
ISSN: 2590-1370
DOI: 10.1016/j.biosx.2023.100390
Popis: Leakage and self-spreading of a cytoplasmic lipid droplet in association with cell death, which was totally invisible in a conventional optical microscope, was discovered by using the recently developed electric-double-layer modulation imaging (EDLMI). The method allowed real-time imaging of the leaked lipid droplet with the thickness of a few nanometers. We demonstrate that the discovered phenomenon is useful as a new cellular sign for diagnosis of cell death.
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