Acute pleiotropic effects of dapagliflozin in type 2 diabetic patients with heart failure with reduced ejection fraction: a crossover trial

Autor:	Fahmida Ilyas, Lynette Jones, Su Ling Tee, Matthew Horsfall, Amy Swan, Fiona Wollaston, Tracy Hecker, Carla De Pasquale, Simeoni Thomas, William Chong, Steve Stranks, Arduino A. Mangoni, Joseph B. Selvanayagam, Derek P. Chew, Carmine G. De Pasquale
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	HFrEF Dapagliflozin Mechanism Acute effects Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	ESC Heart Failure, Vol 8, Iss 5, Pp 4346-4352 (2021)
Druh dokumentu:	article
ISSN:	2055-5822
DOI:	10.1002/ehf2.13553
Popis:	Abstract Aims This study aimed to explore the rapid effects of dapagliflozin in heart failure with reduced ejection fraction (HFrEF). Methods and results We studied the functional, echocardiographic, electrophysiological, lung ultrasound, ambulatory blood pressure (BP), microvascular and macrovascular function, and biochemical effects of 2 week treatment with dapagliflozin in 19 type 2 diabetic HFrEF patients in a double‐blind, crossover, placebo‐controlled trial. Dapagliflozin had no significant effect on clinical, functional, or quality of life parameters. Dapagliflozin reduced systolic BP [114 (105, 131) vs. 106 (98, 113) mmHg, P
Databáze:	Directory of Open Access Journals
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