| Autor: |
Cecília Artico Banho, Beatriz de Carvalho Marques, Lívia Sacchetto, Ana Karoline Sepedro Lima, Maisa Carla Pereira Parra, Alex Ranieri Jeronimo Lima, Gabriela Ribeiro, Antonio Jorge Martins, Claudia Renata dos Santos Barros, Maria Carolina Elias, Sandra Coccuzzo Sampaio, Svetoslav Nanev Slavov, Evandra Strazza Rodrigues, Elaine Vieira Santos, Dimas Tadeu Covas, Simone Kashima, Ricardo Augusto Brassaloti, Bruna Petry, Luan Gaspar Clemente, Luiz Lehmann Coutinho, Patricia Akemi Assato, Felipe Allan da Silva da Costa, Rejane Maria Tommasini Grotto, Mirele Daiana Poleti, Jessika Cristina Chagas Lesbon, Elisangela Chicaroni Mattos, Heidge Fukumasu, Marta Giovanetti, Luiz Carlos Junior Alcantara, Jayme A. Souza-Neto, Paula Rahal, João Pessoa Araújo, Fernando Rosado Spilki, Benjamin M. Althouse, Nikos Vasilakis, Maurício Lacerda Nogueira |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2059-0105 |
| DOI: |
10.1038/s41541-024-00933-w |
| Popis: |
Abstract Since 2021, the emergence of variants of concern (VOC) has led Brazil to experience record numbers of in COVID-19 cases and deaths. The expanded spread of the SARS-CoV-2 combined with a low vaccination rate has contributed to the emergence of new mutations that may enhance viral fitness, leading to the persistence of the disease. Due to limitations in the real-time genomic monitoring of new variants in some Brazilian states, we aimed to investigate whether genomic surveillance, coupled with epidemiological data and SARS-CoV-2 variants spatiotemporal spread in a smaller region, can reflect the pandemic progression at a national level. Our findings revealed three SARS-CoV-2 variant replacements from 2021 to early 2022, corresponding to the introduction and increase in the frequency of Gamma, Delta, and Omicron variants, as indicated by peaks of the Effective Reproductive Number (Reff). These distinct clade replacements triggered two waves of COVID-19 cases, influenced by the increasing vaccine uptake over time. Our results indicated that the effectiveness of vaccination in preventing new cases during the Delta and Omicron circulations was six and eleven times higher, respectively, than during the period when Gamma was predominant, and it was highly efficient in reducing the number of deaths. Furthermore, we demonstrated that genomic monitoring at a local level can reflect the national trends in the spread and evolution of SARS-CoV-2. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink