Adjuvant radiotherapy for patients with pathologic node‐negative esophageal carcinoma: A population based propensity matching analysis

Autor: Hui‐Jiang Gao, Xiao‐Bin Shang, Lei Gong, Hong‐Dian Zhang, Peng Ren, Guo‐Dong Shi, Yu‐Cheng Wei, Zhen‐Tao Yu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Thoracic Cancer, Vol 11, Iss 2, Pp 243-252 (2020)
Druh dokumentu: article
ISSN: 1759-7714
1759-7706
DOI: 10.1111/1759-7714.13235
Popis: Background The impact of adjuvant treatment for esophageal carcinoma with tumor‐negative lymph nodes after upfront radical esophagectomy is still uncertain. This study investigated the effects of postoperative radiotherapy in pT1‐3N0 esophageal carcinoma after radical resection. Method We retrospectively identified pT1‐3N0M0 esophageal carcinoma patients between 2000 and 2016 from the Surveillance, Epidemiology, and End Results database. Patients with upfront esophagectomy were categorized as having received surgery alone (SA) and surgical resection followed by adjuvant radiotherapy (SA + RT). Propensity score matching, univariate and multivariate analysis were performed to compare overall survival (OS) and cause‐specific survival (CSS). Results A total of 2862 patients were identified, of whom 274 received SA + RT and 2588 received SA. The median follow‐up was 60.4 months (95%CI, 58.7–62.1 months). The five‐year OS and CSS were better for SA group compared with SA + RT group (P
Databáze: Directory of Open Access Journals
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