| Autor: |
Pedro Luiz Spinelli Coelho, Gustavo Lacerda da Silva Calestini, Fernando Salgueiro Alvo, Jefferson Michel de Moura Freitas, Paula Marcela Vilela Castro, Tulio Konstantyner |
| Jazyk: |
English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Revista Paulista de Pediatria, Vol 33, Iss 4, Pp 474-482 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1984-0462 |
| DOI: |
10.1016/j.rpped.2015.02.006 |
| Popis: |
Objective: To identify and quantify the adverse effects associated with the recombinant human papillomavirus (types 6, 11, 16 and 18) vaccine in adolescents. Data source: Systematic review of randomized clinical trials from PubMed, SciELO and Lilacs databases. Articles investigating the safety of the vaccine in subjects under 18 years and comparing the recombinant human papillomavirus types 6, 11, 16 and 18 vaccine with a control group were included. Meta-analyses were performed for the outcomes of pain, erythema, swelling and fever, using clinical trials with maximum Jadad score. Data synthesis: Fourteen studies were included. The most common adverse effects related to the human papillomavirus vaccine were effects with no severity (pain, erythema, edema, and fever). Five studies were used for the meta-analyses: pain-risk difference (RD)=11% (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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