Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth
| Autor: | Su-Jung Shin, Woocheol Lee, Jae-Il Lee, Seung-Ho Baek, Kee-Yeon Kum, Won-Jun Shon, Kwang-Shik Bae |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Restorative Dentistry & Endodontics, Vol 36, Iss 3, Pp 196-202 (2011) |
| Druh dokumentu: | article |
| ISSN: | 2234-7658 2234-7666 |
| DOI: | 10.5395/JKACD.2011.36.3.196 |
| Popis: | Objectives The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in root canal exudates during root canal treatment (RCT) of nonvital, painful teeth. Materials and Methods Patients scheduled for nonsurgical RCT were prospectively selected; the study was performed after obtaining informed consent from the patients and was approved by the Institutional Review Board for Clinical Research of Gangnam Severance Hospital, Yonsei University (3-2008-0118). Canal exudates samples were collected using sterilized paper points from teeth scheduled for RCT across three different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis (p < 0.05). Results MMP-8 and SP levels in GCF were decreased during RCT (p < 0.0001), and they showed a weak positive correlation to each other (p < 0.05). Patients'subjective pain levels and the response from percussion test were significantly related to SP level. Conclusions This study demonstrated that periradicular inflammation endodontic origin can elevate SP and MMP-8 levels in root canal exudates. Interestingly, SP level of canal exudates showed a possibility of being used as an indicator of pain due to periapical pathosis. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|