| Autor: |
Ingmar Fortmann, Marie-Theres Dammann, Alexander Humberg, Bastian Siller, Guido Stichtenoth, Geraldine Engels, Janina Marißen, Kirstin Faust, Kathrin Hanke, Sybelle Goedicke-Fritz, Christoph Derouet, Sascha Meyer, Regine Stutz, Elisabeth Kaiser, Egbert Herting, Wolfgang Göpel, Christoph Härtel, Michael Zemlin, on behalf of the German Neonatal Network (GNN) and the PRIMAL Consortium |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Vaccines, Vol 9, Iss 5, p 493 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2076-393X |
| DOI: |
10.3390/vaccines9050493 |
| Popis: |
This study is aimed at detecting the rate of untimely immunization in a large cohort of extremely low gestational age neonates (ELGANs) of the German Neonatal Network (GNN) and at addressing risk factors for delayed vaccination and associated long-term consequences. We performed an observational study of the GNN between 1st January 2010 and 31st December 2019. The immunization status for the hexavalent and pneumococcal immunization was evaluated in n = 8401 preterm infants n = 824 (9.8%) ELGANs did not receive a timely first immunization with the hexavalent and pneumococcal vaccine. Risk factors for delayed vaccination were SGA status (18.1% vs. 13.5%; OR 1.3; 95% CI: 1.1–1.7), impaired growth and surrogates for complicated clinical courses (i.e., need for inotropes, necrotizing enterocolitis). At 5 years of age, timely immunized children had a lower risk of bronchitis (episodes within last year: 27.3% vs. 37.7%; OR 0.60, 95% CI: 0.42–0.86) but spirometry measures were unaffected. In conclusion, a significant proportion of ELGANs are untimely immunized, specifically those with increased vulnerability, even though they might particularly benefit from the immune-promoting effects of a timely vaccination. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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