Glycated hemoglobin A1c, cerebral small vessel disease burden, and disease severity in Parkinson's disease

Autor: Xinxin Ma, Shuhua Li, Fengzhi Liu, Yu Du, Haibo Chen, Wen Su
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Annals of Clinical and Translational Neurology, Vol 10, Iss 12, Pp 2276-2284 (2023)
Druh dokumentu: article
ISSN: 2328-9503
DOI: 10.1002/acn3.51913
Popis: Abstract Objective Our study aimed to investigate the glucose levels in PD and controls. We also examine whether glucose control is associated with PD severity regardless of diabetic status, and test whether the correlation is mediated by cerebral small vessel disease (CSVD) burden. Methods A total of 100 patients with idiopathic PD and 100 age‐ and sex‐matched controls who underwent brain magnetic resonance imaging (MRI) were enrolled in this study. We collected the clinical data and blood parameters, including fasting blood glucose (FBG), glycated hemoglobin A1c (HbA1c), and blood lipid. Patients with PD were divided into early (n = 61) and advanced (n = 39) subgroups, based on Hoehn and Yahr (H&Y) stages. Differences between the PD and controls, PD with and without diabetes, and between two PD subgroups were compared. CSVD markers were assessed, including lacunes, white matter hyperintensities, enlarged perivascular spaces, and cerebral microbleeds. Multivariable logistic regressions were used to test the association between HbA1c and H&Y stages. Interaction between HbA1c and CSVD burden in relation to H&Y stages was also analyzed. Results PD group exhibited higher HbA1c (p
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